[20pts]
a. Hemophilia is an example of common sex-linked disorder that is X-linked recessive trait . It is described as impairing of blood clotting process. A person suffering from hemophilia could die from loss of blood even from a small wound because the blood either clots very slow or not clot at all. A descendant of Queen Victoria who is a hemophiliac male married a commoner female. Using the Punnett Square below, show the possible offspring of the said parents.
Genotypes:
Phenotypes:
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Answer:
Haemophilia was previously regarded as a classical example of Mendelian inheritance, with mutation in only a single gene (F8 or F9) causing the disease phenotype. The disease manifests complete penetrance. Studies, however, revealed the striking genetic and phenotypic heterogeneities of the disease.
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